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Dosing Reference: Trulicity vs Retatrutide | Parameter | Trulicity (Dulaglutide) | Retatrutide | |---|---|---| | Route | Subcutaneous, once weekly | Subcutaneous, once weekly | | Starting dose | 0.75 mg | 2 mg (Phase 2 protocol) | | Maximum dose | 4.5 mg | 12 mg (Phase 2) | | Titration interval | Every 4 weeks | Every 4 weeks | | Approved indication | T2D, CV risk reduction | Not approved (Phase 3) | | Storage | Refrigerated or room temp (up to 14 days) | Refrigerated (Phase 2 trial supply) | | Pen device | Single-dose autoinjector | Single-dose autoinjector (trial formulation) | What the Guidelines Currently Say The ADA 2024 Standards of Care recommend GLP-1 receptor agonists with proven cardiovascular benefit as preferred second-line agents after metformin in patients with type 2 diabetes and atherosclerotic cardiovascular disease [4]

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