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Possible side effects Most side effects reported in clinical trials and reviews are uncommon and mild, but theyre still important to know about.14 21 Potential reactions include: Digestive changes , such as gas, bloating, softer stools, and (less often) constipation as your gut adjusts Abdominal discomfort or nausea , particularly with higher doses or if taken on an empty stomach If you notice new or worsening symptoms particularly significant abdominal pain, blood in the stool, black stools, weight loss, or persistent vomiting its important to stop the supplement and talk with a healthcare professional rather than assume a different enzyme will fix the problem

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For example, the role of EAAT3 was explored in brain tumour models, but the studies focused on glutamate transport and the central nervous system-specific glutamatergic cycle, 35,36 which is essential for the ultimate production of neurotransmitters