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In fact, studies have shown that eating 400 mcg of folic acid from food alone does not raise the serum folic acid concentration anywhere close to that obtained by simple folic acid supplementation

Psychoneuroendocrinology 38 : 12591270

To stay safe: Follow daily dose limits Space doses evenly through the day Read labels to avoid doubling up on multi-symptom products Avoid mixing with alcohol These simple steps make a strong difference in long-term health

Dose increases within the range determined by the prescribing physician may be considered for patients who are tolerating the medication well, based on provider assessment