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A few points on Vitamin B12 deficiency: Vitamin B12 (cobalamin) is important for cellular metabolism (DNA synthesis), mitochondrial metabolism as well as neuronal health

Individuals with fatigue, low B12 levels, absorption issues , or metabolic concerns may benefit

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Those who reported no improvement in global well-being had a minimal change in vitamin B12 levels, no significant improvement in the physical functioning scale of the RAND-36, no significant increase in number of steps, and no significant improvement in the CIS20r fatigue scale