Moreover, compared to c[Glu 22 Lys 26 ] Gly 8 GLP-1, the affinity and activity of c[Asp 22 Lys 26 ] Gly 8 GLP-1 are lower while those of c[hGlu 22 Lys 26 ] Gly 8 GLP-1 are higher (hGlu: homoglutamic acid), 36 indicating that the length of the amino acid side chain is an important factor
However, the included RCTs reported no cases of medullary thyroid carcinoma in either the tirzepatide or the control groups
[2] Klicek, R., Sever, M., Radic, B., & Sikiric, P
Evidence based on recent studies Intestinal obstruction Initially, cases of intestinal obstruction associated with GLP-1 RAs were reported by the European Medicines Agency (EMA) in 2013 [9], and this safety signal is currently being monitored by the United States (US) FDA