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While the science is promising, most evidence comes from small-scale or preclinical studies rather than large clinical trials

In simulations at 350 K, presence of the modification was associated with greater instability in the SpyTag conformation at the reaction center

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At present, the family consists of six sub-families comprising a total of 13 separate isoforms that differ in their mode of activation, expression levels, catalytic regulation, cellular localization, membrane binding avidity and tissue distribution