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The decrease of the availability of glutathione that accompanies mercury exposure becomes compounded by the fact that mercury is removed by glutathione in the normal situation

In particular this means avoiding prolonged periods of conservative management of change in the nail or periungual tissues that are limited to one digit and do not respond promptly to appropriate treatment

Statements Author contributions XuW: Writing original draft, Writing review & editing

Research and Evidence Gaps Long-term outcomes of clinical versus surgical diagnosis strategies require additional research to fully establish the safety and effectiveness of different approaches