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But what these data show is that despite the fact that leptin by itself doesnt work very well, there is a possibility of using co-agonists as a therapeutic strategy. Leptin is a hormone that the body releases to signal to the brain that it has enough fat stored

In rare cases, patients may experience allergic reactions to the injection

In summary, these observations underline the tight interrelation of endocrine signaling and immune responses and, furthermore, indicate common disease mechanism for metabolic and immune-mediated disorders

however, all but 1 patient had a height SDS greater than 3.0 and all had genetically confirmed SPIGFD