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Prog Neuropsychopharmacol Biol Psychiatry 2006;30:1039-42

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A meta-analysis study of CKD patients (both dialytic and non-dialytic) involving 14 randomized controlled trials showed that compared to the placebo group, biotics supplementation had no statistically significant effect on the levels of circulating IS, but a substantial decrease was associated with circulating p-CS concentration

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