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61 The ongoing SURPASS trials evaluating tirzepatide also evidenced a trend towards cardiovascular safety with decreased incidence of MACEs (hazard ratio 0.80

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When LMP or lysosomal rupture occurs, cathepsins are released from lysosomes and cleave BH3-interacting domain death agonist (BID) into tBid fragments, which promote the oligomorphism of B-cell lymphoma-2 (Bcl-2)-associated X protein 6