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Topical copper tripeptide application in irradiated tissue models restored fibroblast activity and collagen deposition comparable to non-irradiated controls

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2,3-Bisphosphoglycerate (2,3-BPG) is an intermediate metabolite present in high concentrations in RBCs (approximately 5 mM) and is the principal allosteric effector for hemoglobin (that is present at almost the same concentration as a tetramer), decreasing its affinity for oxygen