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PloS One 12, 124

Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above

Phase I and II detox genes: conversion and excretion speed Phase I CYP450 enzymes especially CYP1A2 and CYP3A4 convert aflatoxins and other mycotoxins into more reactive intermediates that are water soluble