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GLP-1 and dual agonists: Insulin needs can fall quickly (often around 30% early on), and bolus timing may need adjustment due to slower gastric emptying

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According to these results, astrocyte dysfunction results in an increase in DA levels, which decreases neuronal activity resulting from the binding of DA to dopamine D2 receptors, 80 which generates neuronal depolarization, reducing DA selectivity at dopamine D1-like receptors and promoting DA inhibition through dopamine D2 receptors, which may contribute to increasing extracellular glutamate levels

If a significant OS benefit is achieved, ivonescimab would unlock a new standard for these post-osimertinib patients moving this high-unmet-need group beyond chemotherapy