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Given the presence of glutathione peroxidase in meibomian glands and conjunctiva and its dependence on intracellular GSH, augmenting ocular surface redox capacity with GSH-C4 may mitigate ROS-driven epithelial stress and thereby support tear-film stability, a hypothesis-generating observation that warrants further study (Nezzar et al., 2017)
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Oral administration may be preferable for gastrointestinal issues, while injections may be more effective for muscle recovery and wound healing
Subsequently, arachidonic acid is esterified into phosphatidylethanolamine-arachidonic acid under ACSL4 catalysis, promoting the accumulation of LPO that drive ferroptosis in OA (Cao et al., 2025)
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