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A patient losing 35 kg on retatrutide may lose more lean mass in absolute terms than a patient losing 20 kg on Mounjaro, even if the percentage of lean mass lost is similar
A structured metabolic nutrition strategy during GLP-1 therapy should include: Protein-first meals structured around daily intake goals Consistent fiber from vegetables, legumes, and whole foods at every meal Adequate daily hydration at minimum 64 to 80 ounces of water Regular meal timing to support gut rhythm and stimulate digestion Daily movement to support gut motility and muscle preservation The Fueled Framework system is built around exactly this kind of structured approach to metabolic nutrition during GLP-1 therapy
In fact, Nrf2 regulates the expression of many antioxidant protection genes in the liver
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