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Produced by the liver in response to GH, it activates the IGF-1R receptor in muscle cells, triggering the PI3K/Akt/mTOR pathway, which stimulates protein synthesis, inhibits proteolysis, and promotes the proliferation of satellite cells (muscle precursors)

The overall appearance of density can increase even without dramatic new follicle activation, simply because existing follicles are producing healthier hair

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Some people report that inconsistent injection technique, such as accidentally injecting into muscle rather than subcutaneous tissue, can alter how quickly the drug absorbs and how long each dose feels effective