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doi: 10.9734/BJPR/2017/32843 230 PeroniDGHufnaglKComberiatiPRoth-WalterF

It is required for pyrimidine nucleoside biosynthesis and has been implicated in the inhibition of apoptosis by preventing the collapse of the inner mitochondrial membrane [63]

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Immune metabolic reprogramming in peripheral immune cells generates large amounts of lactate and pro-inflammatory cytokines, which can not only exacerbate peripheral mitochondrial dysfunction but also cross the compromised BBB to regulate glial cell activation and neuronal mitochondrial function in the central nervous system