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Nausea is one of the most frequently reported side effects, affecting approximately 50% of patients taking GLP-1 medications, whilst vomiting occurs in about 15-25% of patients

Microdosing is more practical with lower concentrations where the unit count is higher and easier to measure

406 Therefore, endogenous GLP-1R signaling in astrocytes plays a critical role in maintaining mitochondrial homeostasis and is dependent on FGF21 to effectively regulate glucose metabolism