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The actions through which GCG produces weight loss in preclinical studies are complex and include central effects and upregulation of FGF21 expression in the liver through mechanisms requiring the hepatic GCGR [44]

Additionally, it promotes fat utilization and may slightly boost energy expenditure, aiding in weight loss

[29] Similar reductions in fasting glucose were noted a 5% reduction in this study, [29] compared to a 5.8% reduction in the 200mg/day group from the previous study