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Because glutamic acid is the main excitatory neurotransmitter in the central nervous system, it is particularly valuable in the development of nerve and psychotropic drugs

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Glutamate and -KG serve as important exchangers in the MAS, and since GLS1 knockdown significantly suppresses NADH and ATP production in cancer cells 143 , the supply of glutamate and -KG for the induction of MAS activity is evidently critical for ATP production in cancer cells (Fig