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Over a mean follow-up period of 39.8 months, semaglutide demonstrated superiority over placebo in reducing the composite endpoint of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke among overweight or obese patients with established cardiovascular disease, but without diabetes
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In neurodegeneration, the readout sits far from the mechanism
However, combining them does not mean their effects will be additive in terms of weight losssemaglutide's appetite-suppressing power is already substantial, and inositol's additional metabolic support may offer modest reinforcement
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