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An additional form of 2-hydroxglutaric aciduria, specifically D-2-hydroxyglutaric aciduria type 2 (D2HGA2), is the result of gain-of-function mutations in the IDH2 (isocitrate dehydrogenase 2) gene

Further research is warranted to elucidate these relationships and optimize individualized treatment strategies

Clinical trials show superior weight loss outcomes compared to tirzepatide alone, though the combination significantly increases gastrointestinal side effects like nausea and vomiting

Retatrutide typically comes as a lyophilized (freeze-dried) powder that must be reconstituted with bacteriostatic water before use