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GLP-1s can also have positive impacts on overall metabolic health and reduce risk factors for diseases like Type 2 diabetes and heart disease

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We are encouraged by the robust reductions in liver fat content and abdominal adipose tissue observed with all three doses of tirzepatide in this population of adults with type 2 diabetes and elevated liver fat content. SURPASS-3 was a 52-week, multi-center, randomized, phase 3, open-label trial evaluating the efficacy and safety of tirzepatide compared to titrated insulin degludeci in adults with type 2 diabetes who have inadequate glycemic control on stable doses of metformin with or without an SGLT-2 inhibitor

The decision depends on factors such as: Starting BMI Weight-loss history Type 2 diabetes or insulin resistance Surgical and anaesthetic risk Medication tolerance Patient preference Long-term treatment goals NICE also emphasises that bariatric surgery assessment should involve a multidisciplinary team with medical, nutritional, psychological and surgical expertise