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The detoxification of xenobiotics and excretion of hydrophilic metabolites is brought about by an initial oxidative step that utilises ROS, followed by conjugation of the intermediate metabolite with glucuronic acid, inorganic sulphur, acetyl groups or GSH via GSH transferases (GST) (70, 154)

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But because they reduce appetite and slow digestion, they can also increase the risk of nutrient deficiencies and muscle loss, which come along with a number of side effects