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Evidencia clnica principal: La evidencia en humanos proviene sobre todo de un ensayo fase II publicado en 2023 en NEJM, con 338 adultos con obesidad (IMC 30 o 27 con comorbilidades) tratados 48 semanas

Context is Everything: Comparing Retatrutide to Other Incretins No compound exists in a vacuum

(Reference: Smith et al., 2000) Key Research Observations Published findings highlight several consistent patterns: Selective GH Release Ipamorelin stimulates growth hormone secretion without strongly affecting other pituitary hormones like ACTH, prolactin, or LH

Journal of Preventive Medicine and Public Health, 45 (6), 353363