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Another derivative, GO-Y030, exhibited stronger inhibitory effects on pancreatic cell lines than curcumin, likely through the suppression of STAT3 signaling pathways (535)

In the Phase 2 Lancet trial, orforglipron 45 mg reduced HbA1c by up to 2.1 percentage points at 26 weeks, exceeding the reduction achieved by dulaglutide 1.5 mg (the active comparator)

Clinical Implications & What I Might Recommend If you are interested in whether GLP-1 drugs might be protective for your brain, heres how Id think about integrating the current data into individualized care