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New users of SGLT2i or GLP-1 RA were defined as patients with an outpatient prescription dispensing (dispensing) for any medication in either drug class and no dispensing in the previous 12 months for any other medication in that class

The dual receptor (GLP-1+ GIP) has more pronounced effects in the brain pic.twitter.com/wS81Pf5cXf Eric Topol (@EricTopol) August 13, 2025 Journal reference: Hansford, R., Buller, S., Tsang, A

In this way, it serves as a proofofconcept that even a peptide or protein drug known to have poor bioavailability can still be delivered orally, and without any modification, if we compensate by delivering a sufficiently high dose

While many people have seen positive results, many patients are reporting unexpected and serious side effects