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Taking Rybelsus exactly as directedon an empty stomach with up to 120 mL water, swallowing the tablet whole, and waiting at least 30 minutes before any food or other medicinesand eating smaller, more frequent meals may help manage these effects

The oral tablet uses a novel absorption enhancer called sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC) to facilitate absorption across the gastric mucosa, overcoming the challenge that peptide medications typically face when taken by mouth

Significance was estimated by one-way, two-way ANOVA, or two-tailed unpaired t-test as appropriate to the experimental design