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Mechanism of Action IGF-1 LR3 and IGF-1 both bind to IGF-1 receptors, the stimulation of which activates pathways, including PI3K/AKT and MAPK, to bring about the following effects: Promotion of glucose uptake and subsequent utilisation Increase in energy production in cells Enhancement of glycolysis Increased protein and lipid synthesis Coordination of nutrient uptake Increase in cell proliferation and differentiation Changes in gene expression that support cell cycle progression and tissue growth

This is a significant quality-of-life outcome, as CPAP adherence is a persistent challenge, studies estimate that 30 to 50 percent of patients prescribed CPAP do not use it consistently

Weight loss also changes metabolic needs over time

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