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Whereas acute insulin treatment may benefit ApoE 4 non-carriers with normal insulin levels, chronic treatment may, in fact, induce insulin resistance [151] perhaps explaining a decline in memory function in response to insulin detemir [162]

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Most prior incretin-family peptides act on one or two of these receptors: Semaglutide (single agonist): GLP-1 receptor only Tirzepatide (dual agonist): GLP-1 + GIP receptors Retatrutide / GLP-3RT (triple agonist): GLP-1 + GIP + glucagon receptors That third receptor glucagon is the key reason researchers describe GLP-3RT as a next-generation tool in incretin pharmacology research