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A bitter taste in the mouth typically stems from other causes, such as gastro-oesophageal reflux disease (GORD), medications, or oral health issues

In order to make GLP-1 better used in the clinic, drug developers modified its structure and developed a series of GLP-1R agonists ( GLP-1, a 30- or 31-amino-acid-long peptide hormone, is a gastrointestinal peptide secreted by the intestinal tract that potentiates insulin release and reduces glucagons concentration in physiological conditions ( Scheme 1

Garrison RJ, Kannel WB, Stokes J 3rd, Castelli WP

Food Protein-polysaccharide Conjugates Obtained via the Maillard Reaction: A Review