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The autophagy inhibitor 3-MA was used to investigate whether liralutide improves IR by improving autophagy

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Mice were fasted for 12 h prior to sacrifice

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These physiological changes may underlie the observed reduction in HFpEF events observed in the main trial

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e.g., hematopoietic progenitors and renal tubules) compared with those tissues (e.g., liver) that only express the reduced folate carrier, which is universally expressed but has poor affinity for UMFA

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