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Abbreviations RM: Recurrent miscarriage EGFR: Epidermal growth factor receptor APS: Antiphospholipid syndrome aCL: Anti-cardiolipin LA: Lupus anticoagulant 2GPI: Anti-2-glycoprotein I PIGF: Placental growth factor IL-6: Interleukin-6 HSC: Hematopoietic stem cells BCAA: Branched-chain amino acids IFN: Interferon IL-12: Interleukin-12 IL-10: Interleukin-10 PAGln: Phenylacetylglutamine LepR: Leptin receptor MSCs: Mesenchymal stromal cells Gprs: G-protein-coupled receptors BM: Bone marrow IBDs: Inflammatory bowel disorders DNMTs: DNA methyltransferase enzymes LGG: Lactobacillus rhamnosus GG IL-23: Interleukin-23 Tregs: Regulatory T cells Th17: T helper 17 PGF: Placental growth factor TML: Trimethyl lysine IL-17: Interleukin-17 PlGF: Placental growth factor AT1R: Angiotensin II type 1 receptor H 2 S: Hydrogen sulfide SAM: S-adenosylmethionine RPL: Recurrent pregnancy loss PF4: Platelet factor 4 APC-R: Activated protein C resistance IL-6: Interleukin-6 IL-1: Interleukin-1 TMA: Trimethylamine PET: Positron emission tomography PVN: Paraventricular nucleus LBP: Lipopolysaccharide-binding protein SHR: Spontaneously hypertensive rats FMT: Fecal microbiota transplantation TLR4: Toll-like receptor 4 SLE: Systemic lupus erythematosus MPV: Mean platelet volume PAMP: Pathogen-associated molecular pattern BAs: Bile acids RAAS: Renin-angiotensin-aldosterone system ROS: Reactive oxygen species MAMPs: Microorganism-associated molecular patterns TLRs: Toll-like receptors EMT: Epithelial-mesenchymal transition CRC: Colon cancer LPS: Lipopolysaccharide DCA: Deoxycholic acid CSCs: Cancer stem-like cells ERK: Extracellular regulated protein kinases MAPK: Mitogen-activated protein kinase PI3K: Phosphatidylinositol 3-kinase AKT: Protein kinase B VE-PTP: Vascular endothelial protein tyrosine phosphatase EMT: Epithelial-mesenchymal transition (VE)-cadherin: Vascular endothelial TWIST1: Twist-related protein 1 EPHA2: Ephrin type-A receptor 2 VEGF: Vascular endothelial growth factor MMPs: Matrix metalloproteinases TGFB: Growth factor beta 1 FMO1: Flavin-containing monooxygenase TMA: Trimethylamine cutC/D: Choline TMA-lyase CntA/B: L-carnitine oxygenase SCFAs: Short-chain fatty acids TMAO: Trimethylamine N-oxide PTB: Pregnant women experiencing preterm birth BV: Bacterial vaginosis GM: Gut microbiota References Sachdeva M, Kaur A, Aggarwal N, Ahluwalia J, Vohra S (2024) Feto-maternal outcomes in pregnancy with factor VII deficiency in a tertiary care institution

Impure or improperly manufactured peptides can lead to inconsistent results, introduce confounding variables, and potentially pose risks in preclinical models

Avoid sugary sodas, alcohol, and caffeinated beverages

The approval process is more complex than typical generic drug reviews because semaglutide was originally created using biological methods, while generic manufacturers use simpler chemical processes