Biologic status would give Retatrutide 12 years of market exclusivitya significant extension beyond the typical 5 years granted to small-molecule drugs like tirzepatide (Mounjaro & Zepbound)
For M2 macrophages, some subtypes of M2 macrophages (M2a, M2c) produce anti-inflammatory factors such as IL10 and TGF, while some subtype (M2b) secrete TNF, IL1, IL6 and IL10 (73)
They found that for FDA approved GLP-1s for weight loss, liraglutide (Saxenda) and semaglutide (Wegovy), the percent of side effects reported was as follows: Nausea: 42.2% Diarrhea: 21.9% Vomiting: also 21.9% Constipation: 8.4% They report that although the incidence of side effects were similar among medications, semaglutide had the greatest risk of nausea, diarrhea, and vomiting, whereas liraglutide had the greatest risk of upper abdominal pain
There is still debate about this matter, though