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Considering the network that bi-directionally links obesity and insulin resistance in the pathogenesis of PCOS, it seems to be particularly appealing a new approach producing, at the same time, satisfactory and permanent weight loss, improvement in insulin resistance and in metabolic profile, with additional favourable outcomes on reproductive and cardiovascular systems (19)

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Germline mutations in the p16 INK4a binding domain of CDK4 in familial melanoma