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Minireview: Finding the Sweet Spot: Peripheral versus Central Glucagon-like Peptide 1 Action in Feeding and Glucose Homeostasis

Moreover, in humans, sDPP-4 appeared to increase obesity and insulin resistance, but it was not associated with systemic metabolic inflammation (IL-6 or CRP levels), evidencing the complexity of the role of sDPP-4 in the inflammatory processes [64]

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However, no head-to-head comparisons of GLP-1RAs and other non-insulin glucose-lowering medications exist for patients with NAFLD and type 2 diabetes