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Patients treated with Januvia exhibited a significant mean decrease from baseline in body weight compared to a significant weight gain in patients administered glipizide (-1.5 kg vs +1.1 kg)

If such hypotheses are correct, administration of a GHSR1a antagonist or a GOAT inhibitor may aid in drug addiction as well as in dieting

Unlike sedative drugs that chemically suppress brain activity, DSIP is believed to interact with the bodys own neuroendocrine systems