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Health and lifestyle information included smoking status (non-smoker vs current smoker), alcohol consumption as units per week, physical activity assessed using the International Physical Activity Questionnaire (IPAQ, expressed in Metabolic Equivalent Total (MET) minutes per week [46], and body mass index (BMI) measured during physical examination

Dr Daniel Lyons, lead researcher from St Vincents University Hospital, Dublin, Ireland, said the results were highly encouraging Our findings suggest that semaglutide, even at modest doses, can offer substantial benefits in managing HS, he said

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In addition to its role in systemic lipid metabolism, p53 inhibits lipid synthesis by suppressing NADPH production