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Cardiac Arrest in a Young Man Following Excess Consumption of Caffeinated Energy Drinks

Traditional drug discovery emphasized high selectivity for a single target, often at the expense of physiological relevance

10.1016/j.cmet.2022.07.013 [DOI] [PubMed] [Google Scholar] Gergs U, Jung F, Buchwalow IB, Hofmann B, Simm A, Treede H, Neumann J (2017) Pharmacological and physiological assessment of serotonin formation and degradation in isolated preparations from mouse and human hearts

At 72 weeks, all doses (6 mg, 12 mg, 36 mg) met the primary endpoint of superior body weight reduction versus placebo and achieved key secondary goals including 10%, 15%, and 20% weight loss and reduced waist circumference