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Key Points Prednisone is a common corticosteroid prescribed to treat inflammatory and autoimmune conditions like asthma, rheumatoid arthritis, and lupus Prednisone can make you gain weight by increasing appetite and fluid retention and changes in fat distribution Diet changes, along with regular exercise, can help manage prednisone-related weight gain Working with a registered weight loss dietitian can provide personalized strategies to slow down weight gain on prednisone When you take prednisone, you may start to notice puffiness in your face and bloating around the belly