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This study aimed to explore the therapeutic potential of the cysteine protease inhibitor aloxistatin as a repurposed drug candidate to combat fibrotic progression in predictive HF models

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-glutaredoxin upregulated the expression of the Nrf2 pathway and its downstream enzymes (CAT, SOD), enhanced endogenous antioxidant defence, increased GSH levels and reduced ROS accumulation [125]

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3MCC is composed of two subunits in a heterododecameric configuration composed of six -subunits and six -subunits ( 6 6 )

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