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Long-term follow-up in the DPPOS showed that adherent metformin users maintained roughly 6.2% weight loss below baseline after 15 years, demonstrating durable but modest results particularly in individuals with insulin resistance and higher BMI

"The potential benefit is real, and it makes biological sense," Gilberto de Lima Lopes, chief of medical oncology at the Sylvester Comprehensive Cancer Center at the University of Miami, told The Washington Post

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