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5 The gut-liver-kidney axis: a pathological network of nutritional metabolic disorders in diabetic kidney disease 5.1 Molecular basis of inter-organ metabolic crosstalk 5.1.1 Systemic circulation of gut-derived metabolites Research on the pathogenesis of diabetic kidney disease (DKD) has shifted from a single-organ perspective to an integrated view of multi-organ network regulation

doi: 10.1016/j.jsb.2015.08.008

Interacting residues and surfaces were determined using the protein interfaces, surfaces and assemblies service PISA at the European Bioinformatics Institute 63 ( and ChimeraX 64