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(ii) the LMet salvage pathway, which recycles LMet from the byproducts of polyamine synthesis (Smethyl-5thioadenosine) [3]

A phase 1 mechanistic study of people with T2D reported a mean weight change at week 28 of 11.2 kg among participants assigned to tirzepatide 15 mg as compared with 6.9 kg for semaglutide 1.0 mg and no change (0 kg) for placebo [38]

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Not recommended for use with warfarin