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Glossary 5-HT serotonin AMPs antimicrobial peptides BAs bile acids BMD bone mineral density BMSCs bone marrow stromal cells -OX -oxidation CREB cAMP response element-binding CTX-1 C-terminal telopeptide of type I collagen DCA deoxycholic acid DC dendritic cell EGFR epidermal growth factor receptor ERK extracellular signal-regulated kinase FMT fecal microbiota transplantation FOS fructooligosaccharides FXR farnesoid X receptor Gclc glutamate-cysteine ligase catalytic subunit GIO glucocorticoid-induced OP GM gut microbiota GNS Gold nanospheres GPCRs G protein coupled receptors GOS galactooligosaccharides GSH glutathione HDAC histone deacetylase IGF-1 insulin-like growth factor-1 IL-6 interleukin-6 LCA lithocholic acid LPS Lipopolysaccharides MAMPs microbial-associated molecular patterns NF-B nuclear factor kappa-B NLRs nucleotide-binding oligomerization domain-like receptors OP Osteoporosis OXPHOS oxidative phosphorylation OVX ovariectomy P1NP N-terminal propeptide PELNs Pueraria lobata PNEs propolis nanoemulsions PPAR- peroxisome proliferator-activated receptor PRRs pattern recognition receptors PTH parathyroid hormone RANKL Receptor Activator of Nuclear Factor-B Ligand RCT randomized controlled trial sBAs secondary bile acids SCFAs short chain fatty acids T2DM type 2 diabetes mellitus TCA tricarboxylic acid TGF transforming growth factor TLR4 Toll-like receptor 4 TLRs Toll-like receptors TMAO Trimethylamine N-oxide TNF- tumor necrosis factor- UDCA ursodeoxycholic acid References 1 CoughlanTDockeryF

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This mechanism is sometimes described separately from the angiogenic pathway because it appears to involve protective signalling at the mucosal layer rather than vascularisation per se though the two are not mutually exclusive in research protocols

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