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The combined action produced better outcomes in both clinical and pathological measurements than either compound alone

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FIGURE 7 Discussion Atopic dermatitis was the first-leading cause of skin diseases disability-adjusted life years (DALYs) in the world in 2017 ( Mounting evidence in laboratory and epidemiology has shown that EGCG exerts many beneficial health effects against UV irradiation, melanoma, psoriasis, as well as AD ( in vivo and in vitro pharmacological studies have demonstrated that EGCG at high concentrations and non-acidic conditions exhibited acute and subacute toxicity and prooxidative activities ( Oxidative stress is caused by the imbalance between ROS generation and antioxidant activity (44)

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