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10.1038/nrm2122 Nat

CLINICAL PRACTICE CONSIDERATIONS Long-term outcomes While strong evidence supports the kidney-protective effects of both SGLT2 inhibitors and GLP-1 receptor agonists, the long-term durability of these benefits remains uncertain (Table 2)

11 Rather than combining two distinct moleculesone a GLP-1RAs and the other a GIP receptor agonistresearchers have engineered novel molecules by modifying the native amino acid sequence of GIP