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Cancer cells, unable to utilize ketone bodies produced by KD for energy due to their aberrant mitochondrial function and diminished enzyme activity, can essentially be starved of glucose

Microbial metabolites modulate the oxidative balance SCFAs display antioxidant and anti-inflammatory effects, while TMAO promotes oxidative stress [33]

10,14 A further action of DMF is to modulate transcription factors that are sensitive to oxidative stress such as hypoxia-inducible-1a and STAT3/STAT1

Subgroup, competing-risk, BMI-stratified, and other sensitivity analyses are designated exploratory and reported with unadjusted p -values, with emphasis on effect sizes and confidence intervals