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In some embodiments, the otic formulation comprises between about 0.0001% to about 1% by weight of the weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

In a social defeat mouse model of affective stress, Rhosin has also been found to rescue behavioral phenotypes, such as impaired novel mouse interactions and avoidance behavior through suppression of the dopamine 1 receptor of medium spiny neurons (D1-MSNs) within the Nucleus Accumbens (NAc) [140]

They can be taken at home without the need for medical supervision, promoting better adherence to supplementation regimens