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It is also worth noting that, in clinical practice, histamine intolerance and MCAS are frequently seen alongside other connective tissue conditions, including hypermobile Ehlers-Danlos syndrome (hEDS) and Postural Orthostatic Tachycardia Syndrome (POTS) a triad that overlaps significantly with lipoedema and warrants consideration in women presenting with complex, multisystem symptoms

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For once-weekly preparations, patients are advised to select a day and approximate time that suits their routine and maintain this schedule